The Oupicky Lab focuses on the broad field of drug delivery and nanomedicine, with emphasis on delivery of therapeutic nucleic acids and drug/nucleic acid combinations. Our research promises to enable or significantly improve a range of therapeutic approaches investigated in the field of nanomedicine. The research in our lab is highly interdisciplinary and covers all development aspects of delivery systems, including synthesis of novel polymers and nanomaterials, evaluation of the delivery activity in vitro and studies of the pharmacokinetics and activity of the delivery vectors in vivo in disease models. We put emphasis on a synthesis of new materials and on understanding the physicochemical properties of delivery systems and their interactions with living systems. Currently active research projects focus on development of nanomedicines for delivery of various combinations of therapeutic agents, including drug-gene, drug-siRNA, drug-miRNA and drug-drug combinations.