The Oupicky Lab – Advanced Drug and Gene Delivery

Oupicky Lab Group photo 2016

David Oupicky, PhD

Welcome

The Oupicky Lab focuses on exploring polymers and nanoparticles for delivery of drugs and nucleic acids. We are especially interested in pharmacologically active polymers (polymeric drugs) and in delivery vectors suitable for delivery of drug/gene, drug/siRNA, and drug/miRNA combinations in the treatment of acute kidney injury, metastatic cancer, liver and lung fibrosis, and inflammatory bowel disease.

News

Ekta Kapoor joined the lab as a new PhD student. Welcome, April 2021
Our new paper on siRNA delivery to treat metastatic pancreatic cancer published in the Journal of Controlled Release. Congratulations to Yu and Siyuan, March 2021
David’s review article on siRNA treatments of pancreatic cancer published in the Journal of Controlled Release. Congratulations, January 2021
Neha Kumari joined the lab as a new PhD student. Welcome, December 2020
Ling’s review article on pulmonary delivery of siRNA published in the Journal of Controlled Release, November 2020
Dr. Huizhen Jia joined the Oupicky lab as a postdoc from PennState, September 2020
Yu Hang defended her PhD dissertation on intraperitoneal drug delivery for the treatment of pancreatic cancer. Congratulations!, July 2020
Dr. Sudipta Panja joined the Oupicky lab as a postdoc from the University of Minnesota, July 2020
Dr. Raj Kumar joined the lab as a postdoc from the University of Michigan. Welcome, June 2020

Selected Recent Publications

Y. Xie, Y. Hang, Y. Wang, R. Sleightholm, D. R. Prajapati, J. Bader, A. Yu, W. Tang, L. Jaramillo, J. Li, R. K. Singh, D. Oupicky. Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy. ACS Nano, 2020, 14, 255-271

Y. Wang, Y. Xie, K. V. Kilchrist, J. Li, C. L. Duvall, D. Oupicky. Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy. ACS Applied Materials & Interfaces, 2020, 12, 4308-4322

Y. Chen, W. Tang, F. Yu, Y. Xie, L. Jaramillo, H. S. Jang, J. Li, B. J. Padanilam, D. Oupicky Determinants of preferential renal accumulation of synthetic polymers in acute kidney injury. International Journal of Pharmaceutics, 2019, 568, 118555

S. Kanvinde, Y. S. Chhonker, R. Ahmad, F. Yu, R. Sleightholm, W. Tang, L. Jaramillo, Y. Chen, Y. Sheinin, J. Li, D. J. Murry, A. B. Singh, D. Oupicky. Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease. Acta Biomaterialia, 2018, 82, 158-170

Y. Wang, Y. Xie, J. Li, Z. Peng, Y. Sheinin, J. Zhou, D. Oupicky. Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy. ACS Nano, 2017, 11, 2227-2238