David Oupicky, PhD

The Oupicky Lab focuses on exploring polymers and nanoparticles for delivery of drugs and nucleic acids. We are especially interested in pharmacologically active polymers (polymeric drugs) and in delivery vectors suitable for delivery of drug/gene, drug/siRNA, and drug/miRNA combinations in the treatment of metastatic cancer and inflammatory bowel disease.


  • Lee’s review article on the role of CXCR4 in pancreatic cancer published in Pharmacology & Therapeutics, May 2017
  • Our new paper on mesoporous silica nanoparticles for drug delivery published in Scientific Reports, April 2017
  • A joint paper with Dr. Casero on biochemical properties of polyamine prodrug nanocarriers published in PLOS One, April 2017
  • Dr. Kaikai Wang from China Pharmaceutical University joined the lab as a visiting scholar, February 2017
  • Yazhe’s paper on tumor-penetrating nanoparticles published in ACS Nano, February 2017
  • Our joint CPU paper on fluorinated polycations for siRNA delivery published in ACS Applied Materials & Interfaces, January 2017
  • Joseph’s paper on AMD3465 prodrug for miRNA delivery published in Molecular Pharmaceutics, January 2017
  • Our joint paper with Dr. Casero on microRNA delivery in combination with polyamine inhibition published in the Journal of Controlled Release, January 2017
  • Daniela Machova from the Institute of Macromolecular Chemistry in Prague joined the lab as an exchange PhD student., September 2016
  • Yan Wang defended her PhD dissertation and moved to her new job at UCSF. Congratulations, September 2016