The Oupicky Lab – Advanced Drug and Gene Delivery

Oupicky Lab Group photo 2016

David Oupicky, PhD

Welcome

The Oupicky Lab focuses on exploring polymers and nanoparticles for delivery of drugs and nucleic acids. We are especially interested in pharmacologically active polymers (polymeric drugs) and in delivery vectors suitable for delivery of drug/gene, drug/siRNA, and drug/miRNA combinations in the treatment of acute kidney injury, metastatic cancer, liver and lung fibrosis, and inflammatory bowel disease.

News

Dr. David Větvička joined the Oupicky lab as a visiting scholar from Charles University in Prague, January 2020
Our paper on intraperitoneal treatment of pancreatic cancer published in ACS Nano. Congratulations to Ying and Yu, January 2020
Our paper on endosomolytic silica nanoparticles for combination RNA delivery published in ACS Applied Materials & Interfaces. Congratulations to Yazhe Wang and Ying Xie, January 2020
Our new paper on the synthesis of polymeric chloroquines published in the Journal of Polymer Science. Congratulations to Fei Yu and her coauthors, October 2019
Rubayat Khan joined the Oupicky lab as a PhD student from the Cancer Biology program. Welcome, September 2019
Drs. Qian Ma and Pengkai Wu joined the Oupicky lab as postdocs. Welcome, July 2019
Our new paper on the determinants of preferential renal accumulation of synthetic polymers in acute kidney injury has been accepted for publication in the International Journal of Pharmaceutics. Congratulations to Yi and her coauthors., July 2019
Weimin and Yu received UNMC Graduate Fellowships. Congratulations, July 2019
Karen Pennington joined the lab as a lab manager and technologist. Welcome, July 2019

Selected Recent Publications

Y. Xie, Y. Hang, Y. Wang, R. Sleightholm, D. R. Prajapati, J. Bader, A. Yu, W. Tang, L. Jaramillo, J. Li, R. K. Singh, D. Oupicky. Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy. ACS Nano, 2020, in press

Y. Wang, Y. Xie, K. V. Kilchrist, J. Li, C. L. Duvall, D. Oupicky. Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy. ACS Applied Materials & Interfaces, 2020, in press

Y. Wang, L. Ding, Z. Li, G. Chen, M. Sun, D. Oupicky. Treatment of acute lung injury and early- and late-stage pulmonary fibrosis with combination emulsion siRNA polyplexes. Journal of Controlled Release, 2019, 314, 12-24

Z. Li, G. Chen, L. Ding, Y. Wang, C. Zhu, K. Wang, J. Li, M. Sun, D. Oupicky. Increased survival by pulmonary treatment of established lung metastasis with dual STAT3/CXCR4 inhibition by perfluorocarbon siRNA nanoemulsions. Molecular Therapy, 2019, 27, 2100-2110

S. Kanvinde, Y. S. Chhonker, R. Ahmad, F. Yu, R. Sleightholm, W. Tang, L. Jaramillo, Y. Chen, Y. Sheinin, J. Li, D. J. Murry, A. B. Singh, D. Oupicky. Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease. Acta Biomaterialia, 2018, 82, 158-170