The Oupicky Lab – Advanced Drug and Gene Delivery

Oupicky Lab Group photo 2016

David Oupicky, PhD

Welcome

The Oupicky Lab focuses on exploring polymers and nanoparticles for delivery of drugs and nucleic acids. We are especially interested in pharmacologically active polymers (polymeric drugs) and in delivery vectors suitable for delivery of drug/gene, drug/siRNA, and drug/miRNA combinations in the treatment of acute kidney injury, metastatic cancer, liver and lung fibrosis, and inflammatory bowel disease.

News

Yu Hang defended her PhD dissertation on intraperitoneal drug delivery for the treatment of pancreatic cancer. Congratulations!, July 2020
Dr. Sudipta Panja joined the Oupicky lab as a postdoc from the University of Minnesota, July 2020
Dr. Raj Kumar joined the lab as a postdoc from the University of Michigan. Welcome, June 2020
The Oupicky lab received a new R01 from the NIDDK/NIH to develop novel treatments of inflammatory bowel disease in collaboration with Prof. Amar Singh’s lab, March 2020
Chinmay Jogdeo has joined the Oupicky lab as a new PhD student. Welcome, February 2020
Ling won the best poster award at the International Symposium on Biomedical Materials in Salt Lake City, February 2020
Dr. David Větvička joined the Oupicky lab as a visiting scholar from Charles University in Prague, January 2020
Our paper on intraperitoneal treatment of pancreatic cancer published in ACS Nano. Congratulations to Ying and Yu, January 2020
Our paper on endosomolytic silica nanoparticles for combination RNA delivery published in ACS Applied Materials & Interfaces. Congratulations to Yazhe Wang and Ying Xie, January 2020

Selected Recent Publications

Y. Xie, Y. Hang, Y. Wang, R. Sleightholm, D. R. Prajapati, J. Bader, A. Yu, W. Tang, L. Jaramillo, J. Li, R. K. Singh, D. Oupicky. Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy. ACS Nano, 2020, 14, 255-271

Y. Wang, Y. Xie, K. V. Kilchrist, J. Li, C. L. Duvall, D. Oupicky. Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy. ACS Applied Materials & Interfaces, 2020, 12, 4308-4322

Y. Wang, L. Ding, Z. Li, G. Chen, M. Sun, D. Oupicky. Treatment of acute lung injury and early- and late-stage pulmonary fibrosis with combination emulsion siRNA polyplexes. Journal of Controlled Release, 2019, 314, 12-24

Z. Li, G. Chen, L. Ding, Y. Wang, C. Zhu, K. Wang, J. Li, M. Sun, D. Oupicky. Increased survival by pulmonary treatment of established lung metastasis with dual STAT3/CXCR4 inhibition by perfluorocarbon siRNA nanoemulsions. Molecular Therapy, 2019, 27, 2100-2110

S. Kanvinde, Y. S. Chhonker, R. Ahmad, F. Yu, R. Sleightholm, W. Tang, L. Jaramillo, Y. Chen, Y. Sheinin, J. Li, D. J. Murry, A. B. Singh, D. Oupicky. Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease. Acta Biomaterialia, 2018, 82, 158-170