2013-present (University of Nebraska Medical Center)

  1. L. Ding, S. Tang, T. A. Wyatt, D. Knoell, D. Oupický Pulmonary siRNA delivery for lung disease: Review of recent progress and challenges. Journal of Controlled Release, 2020, in press
  2. P. Wu, X. Luo, H. Wu, Q. Zhang, K. Wang, M. Sun, D. Oupicky Combined hydrophobization of polyethylenimine with cholesterol and perfluorobutyrate improves siRNA delivery. Bioconjugate Chemistry, 2020, 31, 698-707
  3. Z. Li, Y. Wang, Y. Shen, C. Qian, D. Oupicky, M. Sun Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti-PD-L1 immunotherapy. Science Advances, 2020, 6(20):eaaz9240
  4. H. S. Jang, M. R. Noh, E. M. Jung, W. Y. Kim, C. Guda, K. W. Foster, D. Oupicky, F. A. Ferrer, B. J. Padanilam. Proximal tubule cyclophilin D regulates fatty acid oxidation in cisplatin acute kidney injury. Kidney International, 2020, 97, 327-339
  5. Y. Xie, Y. Hang, Y. Wang, R. Sleightholm, D. R. Prajapati, J. Bader, A. Yu, W. Tang, L. Jaramillo, J. Li, R. K. Singh, D. Oupicky. Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy. ACS Nano, 2020, 14, 255-271
  6. Y. Wang, Y. Xie, K. V. Kilchrist, J. Li, C. L. Duvall, D. Oupicky. Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy. ACS Applied Materials & Interfaces, 2020, 12, 4308-4322
  7. Y. Wang, Y. Xie, J. Williams, Y. Hang, L. Richter, M. Becker, C. Amador, D. Oupicky, R. K. Hyde. Use of Polymeric CXCR4 Inhibitors as siRNA Delivery Vehicles for the Treatment of Acute Myeloid Leukemia. Cancer Gene Therapy, 2020, 27, 45-55
  8. F. Yu, Y. Wang, Y. Hang, W. Tang, Z. Zhao, D. Oupicky. Synthesis and Biological Characterization of Clicked Chloroquine Copolymers as Macromolecular Inhibitors of Cancer Cell Migration. Journal of Polymer Science A, 2019, 57, 2235-2242
  9. Y. Wang, L. Ding, Z. Li, G. Chen, M. Sun, D. Oupicky. Treatment of acute lung injury and early- and late-stage pulmonary fibrosis with combination emulsion siRNA polyplexes. Journal of Controlled Release, 2019, 314, 12-24
  10. Z. Li, G. Chen, L. Ding, Y. Wang, C. Zhu, K. Wang, J. Li, M. Sun, D. Oupicky. Increased survival by pulmonary treatment of established lung metastasis with dual STAT3/CXCR4 inhibition by perfluorocarbon siRNA nanoemulsions. Molecular Therapy, 2019, 27, 2100-2110
  11. Y. Chen, W. Tang, F. Yu, Y. Xie, L. Jaramillo, H. S. Jang, J. Li, B. J. Padanilam, D. Oupicky Determinants of preferential renal accumulation of synthetic polymers in acute kidney injury. International Journal of Pharmaceutics, 2019, 568, 118555
  12. M. J. Baine, R. Sleightholm, B. Neilsen, D. Oupicky, L. M. Smith, V. Verma, C. Lin. Stereotactic Body Radiotherapy Versus Nonradiotherapeutic Ablative Procedures (Laser/Cryoablation and Electrocautery) for Early Stage Non-Small Cell Lung Cancer. Journal of the National Comprehensive Cancer Network, 2019, 17, 450-458
  13. Z. Li, Y. Shen, Y. Wang, L. Zhu, C. Zhu, C. Qian, M. Sun, D. Oupicky. Perfluorocarbon nanoemulsions for combined pulmonary siRNA treatment of lung metastatic osteosarcoma. Advanced Therapeutics, 2019, 2, 1900039
  14. L. Flores, R. Sleightholm, B. Neilsen, M. Baine, A. Drincic, W. Thorell, N. Shonka, D. Oupicky, C. Zhang. Highly Aggressive and Radiation-resistant, Atypical and Silent Pituitary Corticotrophic Carcinoma: A Case Report and Review of the Literature. Case Reports in Oncology, 2019, 12, 139-146
  15. Y. Zou, L. Wan, J. Blacklock, L. Xie, S. Carroll, D. Oupicky, G. Mao. In Situ AFM Analysis Investigating Disassembly of DNA Nanoparticles and Nanofilms. Methods in Molecular Biology, 2019, 1943, 199-209
  16. Y. Z. Yu, J. J. Yan, F. Yu, Z. Q. Yu, D. Oupicky. Synthesis of Bioreducible Polycations with Controlled Topologies. Methods in Molecular Biology, 2019, 1943, 27-38
  17. H. Li, Z. Zhou, F. Zhang, Y. Guo, X. Yang, H. Jiang, F. Tan, D. Oupicky, M. Sun. A networked swellable dextrin nanogels loading Bcl2 siRNA for melanoma tumor therapy. Nano Research, 2018, 11, 4627–4642
  18. Z. Zhou, C. Li, M. Zhang, Q. Zhang, C. Qian, D. Oupicky, M. Sun. ATP-activated decrosslinking and charge-reversal vectors for siRNA delivery and cancer therapy. Theranostics, 2018, 8, 4604-4619
  19. H. Li, X. Yang, F. Gao, C. Qian, C. Li, D. Oupicky, M. Sun. Bioreduction-ruptured nanogel for switch on/off release of Bcl2 siRNA in breast tumor therapy. Journal of Controlled Release, 2018, 292, 78-90
  20. Z. Zhou, Q. Zhang, M. Zhang, H. Li, G. Chen, C. Qian, D. Oupicky, M. Sun. Charge and Assembly Reversible Micelles Fueled by Intracellular ATP for Improved siRNA Transfection. ACS Applied Materials & Interfaces, 2018, 10, 32026-32037
  21. Y. Xie, Y. Wang, J. Li, Y. Hang, L. Jaramillo, C. J. Wehrkamp, M. A. Phillippi, A. M. Mohr, Y. Chen, G. A. Talmon, J. L. Mott, D. Oupicky. Cholangiocarcinoma therapy with nanoparticles that combine downregulation of MicroRNA-210 with inhibition of cancer cell invasiveness. Theranostics, 2018, 8, 4305-4320
  22. P. Wu, X. Luo, H. Wu, F. Yu, K. Wang, M. Sun, D. Oupicky. Cholesterol modification enhances antimetastatic activity and siRNA delivery efficacy of poly(ethylenimine)-based CXCR4 antagonists. Macromolecular Bioscience, 2018, 1800234
  23. Y. Chen, J. Li, D. Oupicky. Conjugate polyplexes with anti-invasive properties and improved siRNA delivery in vivo. Bioconjugate Chemistry, 2018, 29, 296-305
  24. J. Li, C. Zhang, J. Chen, W. He, H. Qiao, K. Wang, D. Oupicky, M. Sun. Coordination-driven assembly of catechol-modified chitosan for kidney-specific delivery of salvianolic acid B to treat renal fibrosis. Biomaterials Science, 2018, 6, 179-188
  25. Y. Zhou, F. Yu, F. Zhang, G. Chen, K. Wang, M. Sun, J. Li, D. Oupicky. Cyclam-modified PEI for combined VEGF siRNA silencing and CXCR4 inhibition to treat metastatic breast cancer. Biomacromolecules, 2018, 19, 392-402
  26. G. Chen, K. Wang, P. Wu, Y. Wang, Z. Zhou, L. Yin, M. Sun, D. Oupicky. Development of fluorinated polyplex nanoemulsions for improved siRNA delivery and cancer therapy. Nano Research, 2018, 11, 3746-3761
  27. G. Chen, K. Wang, Y. Wang, P. Wu, M. Sun, D. Oupicky. Fluorination enhances serum stability of bioreducible poly(amido amine) polyplexes and enables efficient intravenous siRNA delivery. Advanced Healthcare Materials, 2018, 7, 1701070
  28. R. N. Kularatne, K. E. Washington, C. Bulumulla, M. C. Biewer, D. Oupicky, M. C. Stefan. Histone Deacetylase Inhibitor (HDACi) Conjugated Polycaprolactone for Combination Cancer Therapy. Biomacromolecules, 2018, 19, 1082-1089
  29. X. Yang, H. Li, C. Qian, Y. Guo, C. Li, F. Gao, Y. Yang, K. Wang, D. Oupicky, M. Sun. Near-infrared light-activated IR780-loaded liposomes for anti-tumor angiogenesis and photothermal therapy. Nanomedicine: NBM, 2018, 14, 1765-1776
  30. S. Kanvinde, Y. S. Chhonker, R. Ahmad, F. Yu, R. Sleightholm, W. Tang, L. Jaramillo, Y. Chen, Y. Sheinin, J. Li, D. J. Murry, A. B. Singh, D. Oupicky. Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease. Acta Biomaterialia, 2018, 82, 158-170
  31. G. Chen, L. Ding, P. Wu, Y. Zhou, M. Sun, K. Wang, D. Oupicky. Polymeric Micelleplexes for Improved Photothermal Endosomal Escape and Delivery of siRNA. Polymers for Advanced Technologies, 2018, 29, 2593-2600
  32. N. K. Routhu, Y. Xie, M. Dunworth, R. A. Casero, D. Oupicky, S. N. Byrareddy. Polymeric Prodrugs Targeting Polyamine Metabolism Inhibit Zika Virus Replication in Epithelial and Glioblastoma Cells. Molecular Pharmaceutics, 2018, 15, 4284-4295
  33. R. Sleightholm, B. Neilsen, D. Oupicky, M. J. Baine. Prognostic and Predictive Factors for Recurrence in Head and Neck Squamous Cell Carcinoma. Head and Neck Cancer, 2018, in press
  34. Y. Xie, Y. Wang, J. Li, Y. Hang, D. Oupicky. Promise of Chemokine Network-Targeted Nanoparticles in Combination Nucleic Acid Therapies of Metastatic Cancer. WIREs Nanomedicine and Nanobiotechnology, 2018, e1528
  35. L. Ding, C. Zhu, F. Yu, P. Wu, G. Chen, A. Ullah, K. Wang, M. Sun, J. Li, D. Oupicky. Pulmonary delivery of polyplexes for combined PAI-1 gene silencing and CXCR4 inhibition to treat lung fibrosis. Nanomedicine: NBM, 2018, 14, 1765-1776
  36. X. Zhou, M. Zhang, Y. Liu, C. Li, Q. Zhang, D. Oupicky, M. Sun. Reversible Covalent-Crosslinked Polycations with Enhanced Stability and ATP-Responsive Behavior for Improved siRNA Delivery. Biomacromolecules, 2018, 19, 3776-3787
  37. G. Chen, Y. Wang, P. Wu, Y. Zhou, F. Yu, C. Zhu, Z. Li, Y. Hang, K. Wang, J. Li, M. Sun, D. Oupicky. Reversibly Stabilized Polycation Nanoparticles for Combination Treatment of Early- and Late-Stage Metastatic Breast Cancer. ACS Nano, 2018, 12, 6620-6636
  38. Y. S. Chhonker, R. L. Sleightholm, J. Li, D. Oupicky, D. J. Murry. Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC–ESI–MS/MS: An application for pharmacokinetic studie3. Journal of Chromatography B, 2018, 1072, 320-327
  39. M. Sun, K. Wang, D. Oupicky. Advances in stimulus-responsive polymeric materials for systemic delivery of nucleic acids. Advanced Healthcare Materials, 2017, 7, 1701070
  40. M. Sun, J. Li, C. Zhang, Y. Xie, H. Qiao, Z. Su, D. Oupicky, Q. Ping. Arginine-Modified Nanostructured Lipid Carriers with Charge-Reversal and pH-Sensitive Membranolytic Properties for Anticancer Drug Delivery. Advanced Healthcare Materials, 2017, 6, 1600693
  41. T. Murray-Stewart, E. Ferrari, Y. Xie, F. Yu, L. J. Marton, D. Oupicky, R. A. Casero. Biochemical evaluation of the anticancer potential of the polyamine based nanocarrier Nano11047. PLOS One, 2017, 12, e0175917
  42. Z. Zhou, H. Li, K. Wang, Q. Guo, C. Li, H.L. Jiang, Y. Hu, D. Oupicky, M. Sun. Bioreducible Cross-Linked Hyaluronic Acid/Calcium Phosphate Hybrid Nanoparticles for Specific Delivery of siRNA in Melanoma Tumor Thera. ACS Applied Materials & Interfaces, 2017, 9, 14576-14589
  43. Y. Xie, F. Yu, W. Tang, B. Alade, Z. Peng, Y. Wang, J. Li, D. Oupicky. Chloroquine-containing DMAEMA copolymers as efficient anti-miRNA delivery vectors with improved endosomal escape and anti-migratory activity in cancer cells. Macromolecular Bioscience, 2017, 18, 1700194
  44. R. L. Sleightholm, B. Yang, F. Yu, Y. Xie, D. Oupicky. Chloroquine-Modified Hydroxyethyl Starch as a Polymeric Drug for Cancer Therapy. Biomacromolecules, 2017, 18, 2247-2257
  45. G. Chen, K. Wang, Q. Hu, L. Ding, F. Yu, Z. Zhou, Y. Zhou, J. Li, M. Sun, D. Oupicky. Combining fluorination and bioreducibility for improved siRNA polyplex delivery. ACS Applied Materials & Interfaces, 2017, 9, 4457-4466
  46. F. Zhang, S. Gong, J. Wu, H. Li, D. Oupicky, M. Sun. CXCR4-targeted and redox responsive dextrin nanogel for metastatic breast cancer therapy. Biomacromolecules, 2017, 18, 1793-1802
  47. H. Li, K. Wang, X. Yang, Y. Zhou, Q. Ping, D. Oupicky, M. Sun. Dual-function nanostructured lipid carriers to deliver IR780 for breast cancer treatment: anti-metastatic and photothermal anti-tumor therapy. Acta Biomaterialia, 2017, 53, 399-413
  48. Z. Peng, Y. Xie, Y. Wang, J. Li, D. Oupicky. Dual-function polymeric HPMA prodrugs for the delivery of miRNA. Molecular Pharmaceutics, 2017, 14, 1395-1404
  49. R. L. Sleightholm, B. K. Neilsen, J. Li, M. M. Steele, R. K. Singh, M. A. Hollingsworth, D. Oupicky. Emerging Roles of the CXCL12/CXCR4 Axis in Pancreatic Cancer Progression and Therapy. Pharmacology & Therapeutics, 2017, 179, 158-170
  50. S. Senevirathne, K. E. Washington, J. B. Miller, M. C. Biewer, D. Oupicky. D. J. Siegwart, M. C. Stefan. HDAC Inhibitor Conjugated Polymeric Prodrug Micelles for Doxorubicin Delivery. Journal of Materials Chemistry B, 2017, 5, 2106-2114
  51. H. Li, X. Yang, Z. Zhou, K. Wang, C. Li, H. Qiao, D. Oupicky, M. Sun. Near-infrared light-triggered drug release from a multiple lipid carrier complex using an all-in-one strategy. Journal of Controlled Release, 2017, 261, 126-137
  52. K. Wang, G. Chen, Q. Hu, Y. Zhen, H. Li, J. Chen, B. Di, Y. Hu, M. Sun, D. Oupicky. Self-assembled hemoglobin nanoparticles for improved oral photosensitizer delivery and photothermal therapy in vivo. Nanomedicine, 2017, 12, 1043-1055
  53. Y. Xie, T. Murray-Stewart, Y. Wang, F. Yu, J. Li, L. J. Marton, R. A. Casero, D. Oupicky. Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy. Journal of Controlled Release, 2017, 246, 110-119
  54. A. Wani, G. H. Layan Savithra, A. Abyad, S. Kanvinde, J. Li, S. Brock, D. Oupicky. Surface PEGylation of Mesoporous Silica Nanorods (MSNR): Effect on loading, release, and delivery of mitoxantrone in hypoxic cancer cells. Scientific Reports, 2017, 7, 2274
  55. Y. Wang, Y. Xie, J. Li, Z. Peng, Y. Sheinin, J. Zhou, D. Oupicky. Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy. ACS Nano, 2017, 11, 2227-2238
  56. F. Yu, Y. Xie, Y. Wang, Z. Peng, J. Li, D. Oupicky. Chloroquine-containing HPMA Copolymers as Polymeric Inhibitors of Cancer Cell Migration Mediated by the CXCR4/SDF-1 Chemokine Axis. ACS Macro Letters, 2016, 5, 342-345
  57. Y. Xie, C. Wehrkamp, J. Li, Y. Wang. Y. Wang, J. Mott, D. Oupicky. Delivery of miR-200c mimic with poly(amido amine) CXCR4 antagonists for combined inhibition of cholangiocarcinoma cell invasiveness. Molecular Pharmaceutics, 2016, 13, 1073-1080
  58. M. Saraswathy, D. Oupicky. Endosomal escape into cytosol. Drug Delivery Across Physiological Barriers, 2016, pp. 341-360
  59. G. Chen, K. Wang, Y. Zhou, L. Ding, A. Ullah, Q. Hu, M. Sun, D. Oupicky. Oral nanostructured lipid carriers loaded with near-infrared dye for image-guided photothermal therapy.. ACS Applied Materials & Interfaces, 2016, 8, 25087-25095
  60. F. Yu, J. Li, R. L. Sleightholm, Y. Xie, D. Oupicky. Polymeric chloroquine as an inhibitor of cancer cell migration and experimental lung metastasis. Journal of Controlled Release, 2016, 244, 347-356
  61. Y. Wang, S. Kumar, S. Rachagani, B. R. Sajja, Y. Xie, Y. Hang, M. Jain, J. Li, M. D. Boska, S. K. Batra, D. Oupicky. Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis. Biomaterials, 2016, 101, 108-120
  62. Y. Wang, Y. Xie, D. Oupicky. Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery. Current Pharmacology Reports, 2016, 2(1), 1-10
  63. Y. Wang, J. Li, Y. Chen, D. Oupicky. Balancing polymer hydrophobicity for ligand presentation and siRNA delivery in dual function CXCR4 inhibiting polyplexes. Biomaterials Science, 2015, 3, 1114-1123
  64. Y. Wang, S. Hazeldine, J. Li, D. Oupicky. Development of functional poly(amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids. Advanced Healthcare Materials, 2015, 4(5), 729-738
  65. J. Li, F. Yu, Y. Chen, D. Oupicky. Polymeric drugs: Advances in the development of pharmacologically active polymers. Journal of Controlled Release, 2015, 219, 369-382
  66. Y. Zhu, J. Li, S. Kanvinde, Z. Lin, S. Hazeldine, R. K. Singh, D. Oupicky. Self-immolative polycations as gene delivery vectors and prodrugs targeting polyamine metabolism in cancer.  Molecular Pharmaceutics, 2015, 12(2), 332-341
  67. S. Senevirathne, S. Boonsith, D. Oupicky, M. C. Biewer, M. C. Stefan. Synthesis and characterization of valproic acid ester substituted amphiphilic polycaprolactone block copolymers. Polymer Chemistry, 2015, 6(13), 2386-2389
  68. Y. Zou, D. Oupicky, G. Mao. Atomic Force Microscopy Imaging of DNA Delivery Nanosystems. NanoCellBiology: Multimodal Imaging in Biology and Medicine, B. P. Jena and D. J. Taatjes, Eds., Pan Stanford Publishing, Chapter 11, 2014,
  69. D. Oupicky, J. Li. Bioreducible Polycations in Nucleic Acid Delivery: Past, Present, and Future Trends.  Macromolecular Bioscience, 2014, 14(7), 908-922
  70. Y. Zhu, S. Hazeldine, J. Li, D. Oupicky. Dendritic Polyglycerol with Secondary Amine Shell as an Efficient Gene Delivery Vector with Reduced Toxicity.  Polymers for Advanced Technologies, 2014, 25(9), 940-947
  71. J. Li, D. Oupicky. Effect of biodegradability on CXCR4 antagonism, transfection efficacy and antimetastatic activity of polymeric Plerixafor.  Biomaterials, 2014, 35(21), 5572-5579
  72. J. Li, A. M. Lepadatu, Y. Zhu, M. Ciobanu, Y. Wang, S. C. Asaftei, D. Oupicky. Examination of structure-activity relationship of viologen-based dendrimers as CXCR4 antagonists and gene carriers.  Bioconjugate Chemistry, 2014, 25(5), 907-917
  73. Y. Wang, J. Li, D. Oupicky. Polymeric Plerixafor: Effect of PEGylation on CXCR4 Antagonism, Cancer Cell Invasion, and DNA Transfection.  Pharmaceutical Research, 2014, 31(12), 3538-3548
  74. Y. Zhu, J. Li, Y. Wang, D. S. Manickam, Y. You, D. Oupicky. Redox-responsive polymer-based gene delivery systems. In Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. 4th Edition, Ed. N. S. Templeton, Taylor and Francis/CRC Press, Boca Raton, 2014,
  75. R. Roggers, S. Kanvinde, S. Boonsith, D. Oupicky. The Practicality of Mesoporous Silica Nanoparticles as Drug Delivery Devices and Progress Toward This Goal.  AAPS PharmSciTech, 2014, 15(5), 1163-1171
  76. C. Wu, J. Li, Y. Zhu, J. Chen, D. Oupicky. Opposing Influence of Intracellular and Membrane Thiols on the Toxicity of Reducible Polycations.  Biomaterials, 2013, 34(34), 8843-50
  77. J. Li, Y. Wang, Y. Zhu, D. Oupicky. Recent Advances in Delivery of Drug-Nucleic Acid Combinations for Cancer Treatment. Journal of Controlled Release, 2013, 172(2), 589-600
  78. J. Yuan, H. Zhang, H. Kaur, D. Oupicky, F. Peng. Synthesis and Characterization of Theranostic Poly(HPMA)-c(RGDyK)-DOTA-64Cu Copolymer Targeting Tumor Angiogenesis: Tumor Localization Visualized by Positron Emission Tomography.  Molecular Imaging, 2013, 12(3), 203-12
  79. M. F. Ebbesen, D. Schaffert, M. L. Crowley, D. Oupicky, K. A. Howard. Synthesis of click-reactive HPMA copolymers using RAFT polymerization for drug delivery applications.  Journal of Polymer Science Part A: Polymer Chemistry, 2013, 51(23), 5091-9

2003-2013 (Wayne State University)

  1. Y. Zou, J. Blacklock, D. Oupicky, G. Mao. In Situ Analysis Investigating Disassembly of DNA Nanoparticles and Nano-Films.. Nanotechnology for Nucleic Acid Delivery: Methods and Protocols, 2013, 183-193
  2. Y. Z. Yu, J. J. Yan, Z. Q. Yu, D. Oupicky. Synthesis of Bioreducible Polycations with Controlled Topologies.. Nanotechnology for Nucleic Acid Delivery: Methods and Protocols, 2013, 121-32
  3. Y. Wu, S. Wang, S. M. Farooq, M. P. Castelvetere, Y. Hou, J. Gao, J. V. Navarro, D. Oupicky, F. Sun, C. Li. A chemokine receptor CXCR2 macromolecular complex regulates neutrophil functions in inflammatory diseases.. Journal of Biological Chemistry, 2012, 278(8), 5744-55. (Abstract)
  4. J. Li, Y. Zhu, S. T. Hazeldine, S. M. Firestine, D. Oupicky. Cyclam-based Polymeric Copper Chelators for Gene Delivery and Potential PET Imaging.. Biomacromolecules, 2012, 13, 3220-7. (Abstract)
  5. J. Li, Y. Zhu, S. Hazeldine, C. Li, D. Oupicky. Dual-function CXCR4 Antagonist Polyplexes to Deliver Gene Therapy and Inhibit Cancer Cell Invasion.. Angewandte Chemie, International Edition, 2012, 51(35), 8740-3. (Abstract)
  6. J. Li, D. S. Manickam, J. Chen, D. Oupicky. Effect of cell membrane thiols and reduction-triggered disassembly on transfection activity of bioreducible polyplexes.. European Journal of Pharmaceutical Sciences, 2012, 46(3), 173-80. (Abstract)
  7. Y. Zhu, J. Li, D. Oupický. Intracellular Delivery Considerations for RNAi Therapeutics.. RNA Interference from Biology to Therapeutics, 2012,
  8. A. Wani, E. Muthuswamy, G. H. L. Savithra, G. Mao, S. Brock, D. Oupicky. Surface Functionalization of Mesoporous Silica Nanoparticles Controls Loading and Release Behavior of Mitoxantrone.. Pharmaceutical Research, 2012, 29(9), 2407-2418. (Abstract)
  9. Y. Dong, Y. Zhu, J. Li, Q. Zhou, C. Wu, D. Oupicky. Synthesis of bisethylnorspermine lipid prodrug as gene delivery vector targeting polyamine metabolism in breast cancer.. Molecular Pharmaceutics, 2012, 9(6), 1654-64. (Abstract)
  10. M. B. Dewal, A. S. Wani, C. Vidaillac, D. Oupicky, M. J. Rybak, S. M. Firestine. Thieno[2,3-d]pyrimidinedione derivatives as antibacterial agents.. European Journal of Medicinal Chemistry, 2012, 51, 145-153. (Abstract)
  11. U. L. Rahbek, A. F. Nielsen, M. Dong, Y. You, A. Chauchereau, D. Oupicky. F. Besenbacher, J. Kjems, K. A. Howard. Bioresponsive hyperbranched polymers for siRNA and miRNA delivery.. Journal of Drug Targeting, 2010, 18(10), 812-20. (Abstract)
  12. Y. Dong, J. Li, C. Wu, D. Oupicky. Bisethylnorspermine lipopolyamine as potential delivery vector for combination drug/gene anticancer therapies.. Pharmaceutical Research, 2010, 27(9), 1927-38. (Abstract)
  13. J. Blacklock, G. Mao, D. Oupicky, H. Möhwald. DNA release dynamics from bioreducible layer-by-layer films.. Langmuir, 2010, 26(11), 8597-8605. (Abstract)
  14. D. S. Manickam, J. Li, D. A. Putt, Q. H. Zhou, C. Wu, L. H. Lash, D. Oupicky. Effect of innate glutathione levels on activity of redox-responsive gene delivery vectors.. Journal of Controlled Release, 2010, 141(1), 77-84. (Abstract)
  15. S. R. Bhattarai, E. Muthuswamy, A. Wani, M. Brichacek, A. L. Castaneda, S. Brock, D. Oupicky. Enhanced gene and siRNA delivery by polycation-modified mesoporous silica nanoparticles loaded with chloroquine.. Pharmaceutical Research, 2010, 27(12), 2556-68. (Abstract)
  16. R. Regmi, S. R. Bhattarai, C. Sudakar, A. S. Wani, R. Cunningham, P. P. Washnava, R. Naik, D. Oupicky, G. Lawes. Hyperthermia Controlled Rapid Drug Release from Thermosensitive Magnetic Microgels.. Journal of Materials Chemistry, 2010, 20, 6158-63. (Abstract)
  17. L. Shin, N. Basi, J. S. Lee, W. J. Cho, Z. Chen, R. Abu-Hamdah, D. Oupicky, B. P. Jena. Involvement of vH+-ATPase in synaptic vesicle swelling.. Journal of Neuroscience Research, 2010, 88(1), 95-101. (Abstract)
  18. D. Oupicky. Polymeric Biomaterials for Gene and Drug Delivery.. Pharmaceutical Research, 2010, 27(12), 2517-19. (Abstract)
  19. M. O. Andersen, A. Lichawska, A. Arpanaei, S. M. Rask Jensen, H. Kaur, D. Oupicky, F. Besenbacher, P. Kingshott, J. Kjems, K. A. Howard. Surface Functionalisation of PLGA Nanoparticles for Gene Silencing.. Biomaterials, 2010, 31(21), 5671-77. (Abstract)
  20. J. Blacklock, A. Vetter, A. Lankenau, D. Oupicky, H. Möhwald. Turning the mechanical properties of bioreducible multilayer films for improved cell adhesion and transfection activity.. Biomaterials, 2010, 31, 7167-74. (Abstract)
  21. J. Chen, C. Wu, D. Oupicky. Bioreducible Hyperbranched Poly(amido amine)s for Gene Delivery.. Biomacromolecules, 2009, 10(10), 2921-27. (Abstract)
  22. J. Blacklock, T. K. Sievers, H. Handa, Y. Z. You, D. Oupicky, G. Mao, H. Möhwald. Cross-Linked Bioreducible Layer-by-Layer Films for Increased Cell Adhesion and Transgene Expression.. Journal of Physical Chemistry B, 2009, 114(16), 5283-91. (Abstract)
  23. Q. H. Zhou, Y. Z. You, C. Wu, Y. Huang, D. Oupicky. Cyclic RGD-targeted reversibly-stabilized nanoparticles enhance cell uptake and transfection in vitro.. Journal of Drug Targeting, 2009, 17(5), 364-373. (Abstract)
  24. L. Wan, Y. Z. You, Y. Zou, D. Oupicky, G. Mao. DNA release dynamics from bioreducible poly(amido amine) polyplexes.. Journal of Physical Chemistry B, 2009, 113(42), 13735-41. (Abstract)
  25. Q. Zhou, C. Wu, D. S. Manickam, D. Oupicky. Evaluation of pharmacokinetics of bioreducible gene delivery vectors by real-time PCR.. Pharmaceutical Research, 2009, 26(7), 1581-1589. (Abstract)
  26. J. Blacklock, Y. Z. You, Q. H. Zhou, G. Mao, D. Oupicky. Gene delivery in vitro and in vivo from bioreducible multilayered polyelectrolyte films of plasmid DNA.. Biomaterials, 2009, 30, 939-950. (Abstract)
  27. S. Kakade, D. S. Manickam, H. Handa, G. Mao, D. Oupicky. Transfection activity of layer-by-layer plasmid DNA/poly(ethylenimine) films deposited on PLGA microparticles.. International Journal of Pharmaceutics, 2009, 365, 44-52. (Abstract)
  28. D. Oupicky. Design and development strategies of polymer materials for drug and gene delivery applications (Preface). Advanced Drug Delivery Reviews, 2008, 60, 957. (Issue)
  29. L. Wan, D. S. Manickam, D. Oupicky, G. Mao. DNA Release Dynamics from Reducible Polyplexes by Atomic Force Microscopy.. Langmuir, 2008, 24, 12474-12482. (Abstract)
  30. U. L. Rahbek, K. A. Howard, D. Oupicky, D. S. Manickam, M. Dong, A. F. Nielsen, F. Besenbacher, J. Kjems. Intracellular siRNA and Precursor miRNA Trafficking Using Bioresponsive Copolypeptides.. Journal of Gene Medicine, 2008, 10, 81-93. (Abstract)
  31. D. S. Manickam, A. Hirata, D. A. Putt, L. H. Lash, F. Hirata, D. Oupicky. Overexpression of Bcl-2 as a proxy redox stimulus to enhance activity of non-viral redox-responsive delivery vectors.. Biomaterials, 2008, 29, 2680-2688. (Abstract)
  32. Oupicky, Y. You, D. Soundara Manickam. Redox-responsive polymer-based gene delivery systems.. Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, 2008,
  33. H. Zhang, R. Thomas, D. Oupicky, F. Peng. Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells.. Journal of Biological Inorganic Chemistry, 2008, 13, 47-55. (Abstract)
  34. Y. You, K. Kalebaila, S. L. Brock, D. Oupicky. Temperature-Controlled Uptake and Release in PNIPAM-modified Porous Silica Nanoparticles.. Chemistry of Materials, 2008, 20, 3354-3359. (Abstract)
  35. Y. You, D. Soundara Manickam, Q. Zhou, D. Oupicky. A versatile approach to reducible vinyl polymers via oxidation of telechelic oligomers prepared by RAFT polymerization.. Biomacromolecules, 2007, 8, 2038-2044. (Abstract)
  36. J. Blacklock, H. Handa, D. Soundara Manickam, G. Mao, A. Mukhopadhy, D. Oupicky. Disassembly of Layer-by-Layer Films of Plasmid DNA and Reducible TAT Polypeptide.. Biomaterials, 2007, 28, 117-124. (Abstract)
  37. Y. Z. You, Q. H. Zhou, D. S. Manickam, L Wan, G. Mao, D. Oupicky. Dually Responsive Multiblock Copolymers via Reversible Addition-Fragmentation Chain Transfer Polymerization: Synthesis of Temperature- and Redox-Responsive Copolymers of Poly(N-isopropylacrylamide) and Poly(2-(dimethylamino)ethyl methacrylate).. Macromolecules, 2007, 40(24), 8617-8624. (Abstract)
  38. K. A. Howard, M. Dong, D. Oupicky, H. S. Bisht, C. Buss, F. Besenbacher, J. Kjems. Nanocarrier Stimuli-Activated Drug Delivery.. Small, 2007, 3, 54-57. (Abstract)
  39. Y. You, D. Soundara Manickam, Q. Zhou, D. Oupický. Reducible poly(2-dimethyl aminoethyl methacrylate): Synthesis, cytotoxicity, and gene delivery activity.. Journal of Controlled Release, 2007, 122, 217-225. (Abstract)
  40. J. Yuan, Y. You, X. Lu, O. Muzik, D. Oupicky, F. Peng. Synthesis of Poly(APMA)-DOTA-64Cu conjugates for interventional radionuclide therapy of prostate cancer: Assessment of intra-tumoral retention by microPET imaging.. Molecular Imaging, 2007, 6, 10-17. (Abstract)
  41. Y. You, D. Oupicky. Synthesis of temperature-responsive heterobifunctional block copolymers of PEG and PNIPAM.. Biomacromolecules, 2007, 8, 98-105. (Abstract)
  42. L. Wan, H. S. Bisht, Y. You, D. Oupicky, G. Mao. Temperature-Reversible Ultrathin Films of N-Isopropylacrylamide Terpolymer Adsorbed at the Solid-Liquid Interface.. Langmuir, 2007, 23, 12159-12166. (Abstract)
  43. M. Dong, K. A. Howard, D. Oupicky, H. Bisht, J. Kjems, F. Besenbacher. Visualisation of thermal activated nanocarriers using in situ atomic force microscopy.. Nanotechnology, 2007, 18(18), 185501 5(pp). (Abstract)
  44. D. Soundara Manickam, D. Oupicky. Multiblock reducible copolypeptides containing histidine-rich and nuclear localization sequences for gene delivery.. Bioconjugate Chemistry, 2006, 17, 1395-1403. (Abstract)
  45. D. Soundara Manickam, D. Oupicky. Polyplex gene delivery modulated by redox potential gradients.. Journal of Drug Targeting, 2006, 14, 519-526. (Abstract)
  46. H. S. Bisht, D. Soundara Manickam, Y. You, D. Oupicky. Temperature-Controlled Properties of DNA Complexes with Poly(ethylenimine)-graft-poly(N-isopropylacrylamide).. Biomacromolecules, 2006, 7, 1169-1178. (Abstract)
  47. M. L. Read, S. Singh, Z. Ahmed, M. Stevenson, S. Briggs, D. Oupicky, L. Barrett, U. Tirlapur, M. Berry, J. Preece, A. Logan, L. W. Seymour. A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids.. Nucleic Acids Research, 2005, 33(9), e86. (Full text)
  48. A. L. Parker, K.D. Fisher, D. Oupicky, M. L. Read, S. A. Nicklin, A. H. Baker, L. W. Seymour. Enhanced gene transfer activity of peptide-targeted gene-delivery vectors.. Journal of Drug Targeting, 2005, 13, 39-51. (Abstract)
  49. D. Soundara Manickam, H. S. Bisht, L. Wan, G. Mao, D. Oupicky. Influence of TAT-peptide polymerization on properties and transfection activity of TAT/DNA polyplexes.. Journal of Controlled Release, 2005, 102, 293-306. (Abstract)
  50. H. S. Bisht, L. Wan, G. Mao, D. Oupicky. pH-Controlled association of PEG-containing terpolymers of N-isopropylacrylamide and 1-vinylimidazole.. Polymer, 2005, 46, 7945-7952. (Abstract)
  51. D. Oupicky, H. S. Bisht, D. Soundara Manickam, Q. Zhou. Stimulus-controlled delivery of drugs and genes.. Expert Opinion on Drug Delivery, 2005, 2, 653-665. (Abstract)
  52. D. Oupicky. Subcellular Fate of Proteins and Nucleic Acids.. Biomaterials-based Delivery and Biocompatibility of Proteins and Nucleic Acids, 2005,
  53. Q. Zhou, D. L. Miller, R. C. Carlisle, L. W. Seymour, D. Oupicky. Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation.. Journal of Controlled Release, 2005, 106, 416-427. (Abstract)
  54. D. Oupicky. Use of HPMA Copolymers in Gene Delivery.. Polymeric Gene Delivery: Principles and Applications, 2004,
  55. L. W. Seymour, K. D. Fisher, N. K. Green, S. J. Hale, M. Lyons, V. Mautner, S. Nicum, D. Onion, D. Oupicky, M. Stevenson, K. Ulbrich Adenovirus Retargeting and Systemic Delivery. Human Gene Therapy: Present opportunities and future trends, 2003, (Abstract)
  56. D. Oupicky, V. Diwadkar. Stimuli-responsive gene delivery vectors.. Current Opinion in Molecular Therapeutics, 2003, 5, 345-350. (Abstract)
  57. D. Oupicky, T. Reschel, C. Konak, L. Oupicka. Temperature controlled behavior of self-assembly gene delivery vectors based on complexes of DNA with poly(L-lysine)-graft-poly(N-isopropylacryl amide).. Macromolecules, 2003, 36, 6863-6872. (Abstract)
  58. M. L. Read, K. H. Bremner, D. Oupicky, N. K. Green, P. F. Searle, L. W. Seymour. Vectors based on reducible polycations facilitate intracellular release of nucleic acids.. Journal of Gene Medicine, 2003, 5, 232-245. (Abstract)

1996-2002 (Institute of Macromolecular Chemistry and University of Birmingham)

  1. D. Oupicky, M. Ogris, L. W. Seymour. Development of long-circulating polyelectrolyte complexes for systemic delivery of genes.. Journal of Drug Targeting, 2002, 10, 93-98. (Abstract)
  2. D. Oupicky, M. Ogris, K. A. Howard, P. R. Dash, K. Ulbrich, and L. W. Seymour. Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation.. Molecular Therapy, 2002, 5, 463-472. (Abstract)
  3. D. Oupicky, A. L. Parker, L. W. Seymour. Laterally stabilized complexes of DNA with linear reducible polycations: Strategy for triggered intracellular activation of DNA delivery vectors.. Journal of the American Chemical Society, 2002, 124, 8-9. (Abstract)
  4. A. L. Parker, D. Oupicky, P. R. Dash, L. W. Seymour. Methodologies for monitoring particle formation by self-assembly of DNA with poly(L-lysine).. Analytical Biochemistry, 2002, 302, 75-80. (Abstract)
  5. C. M. Ward, M. Pechar, D. Oupicky, K. Ulbrich and L. W. Seymour. Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo.. Journal of Gene Medicine, 2002, 4, 536–547. (Abstract)
  6. T. Reschel, C. Konak, D. Oupicky, L.W. Seymour , K. Ulbrich. Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations.. Journal of Controlled Release, 2002, 81 201-217. (Abstract)
  7. C. Konak, T. Reschel, D. Oupicky, K. Ulbrich. Thermally controlled association in aqueous solutions of poly(L-lysine) grafted with poly(N-isopropylacrylamide).. Langmuir, 2002, 18, 8217-8222. (Abstract)
  8. M. L. Read, T. Bettinger, D. Oupicky. Methods for studying the formation and stability of polycation-DNA complexes.. Methods in Molecular Medicine, 2001,
  9. D. Oupicky, M. L. Read, T. Bettinger. Stabilization of polycation/DNA complexes by surface modification with hydrophilic polymers.. Methods in Molecular Medicine, 2001,
  10. D. Oupicky, R. C. Carlisle, L.W. Seymour. Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo.. Gene Therapy, 2001, 8(9), 713-724. (Abstract)
  11. J. Kriz, D. Kurková, J. Dybal, D. Oupicky. Cooperative interactions of unlike macromolecules: NMR study of ionic coupling of poly[2-(trimethylammonio)ethyl methacrylate chloride]-block-poly(N-(2-hydroxypropyl) methacrylamide) polycation with oligophosphates in D2O.. Journal of Physical Chemistry A, 2000, 104, 10972-10985. (Abstract)
  12. P. R. Dash, M. Read, K. Fisher, K. Howard, M. Wolfert, D. Oupicky, M. Šubr, J. Strohalm, K. Ulbrich and L. W. Seymour. Decreased binding to proteins and cells of polymeric gene delivery vectors surface-modified with a multivalent hydrophilic polymer.. Journal of Biological Chemistry, 2000, 275, 3793-3802. (Full text)
  13. D. Oupicky, C. Konak, K. Ulbrich, M. A. Wolfert, L. W. Seymour. DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers.. Journal of Controlled Release, 2000, 65, 149-171. (Abstract)
  14. M. L. Read, P. Dash, A. Clark, K. Howard, D. Oupicky, V. Toncheva, O. Alpar, E. H. Schacht, K. Ulbrich and L. W. Seymour. Physicochemical and biological characterisation of an antisense oligonucleotide targeted against the bcl-2 mRNA complexed with cationic-hydrophilic copolymers.. European Journal of Pharmaceutical Sciences, 2000, 10, 169-177. (Abstract)
  15. K. Ulbrich, J. Strohalm, D. Plocová, D. Oupicky, V. Šubr, J. Soucek, P. Poucková, J. Matoušek. Poly[N-(2-hydroxypropyl)methacrylamide] conjugates of bovine seminal ribonuclease. Synthesis, physicochemical, and preliminary biological evaluation.. Journal of Bioactive and Compatible Polymers, 2000, 15, 4-26. (Abstract)
  16. D. Oupicky, K. A. Howard, C. Konak, P. R. Dash, K. Ulbrich, L.W. Seymour. Steric stabilization of poly-L-lysine/DNA complexes by covalent attachment of semitelechelic poly[N-(2-hydroxypropyl)methacryl-amide].. Bioconjugate Chemistry, 2000, 11, 492-501. (Abstract)
  17. C. Konak, D. Oupicky, V. Chytry, K. Ulbrich, M. Helmstedt. Thermally controlled association in aqueous solutions of diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropylacryl-amide).. Macromolecules, 2000, 33, 5318-5320. (Abstract)
  18. D. Oupicky, K. Ulbrich, B. Rihova. Conjugates of semitelechelic poly[N-(2-hydroxypropyl) methacrylamide] with enzymes for protein delivery.. Journal of Bioactive and Compatible Polymers, 1999, 14, 213-231. (Abstract)
  19. D. Oupicky, C. Konak, K. Ulbrich. DNA complexes with block and graft copolymers of N-(2-hydroxypropyl)methacrylamide and 2-(trimethylammonio)ethyl methacrylate.. Journal of Biomaterials Science: Polymer Edition, 1999, 10, 573-590. (Abstract)
  20. D. Oupicky, C. Konak, P. R. Dash, L. W. Seymour, K. Ulbrich. Effect of albumin and polyanions on the structure of DNA complexes with polycation containing hydrophilic nonionic blocks.. Bioconjugate Chemistry, 1999, 10(5), 764-772. (Abstract)
  21. M. A. Wolfert, P. R. Dash, O. Nazarova, D. Oupicky, L. W. Seymour, S. Smart, J. Strohalm, K. Ulbrich. Polyelectrolyte vectors for gene delivery: Influence of cationic polymer on biophysical properties of complexes formed with DNA.. Bioconjugate Chemistry, 1999, 10, 993-1004. (Abstract)
  22. D. Oupicky, C. Konak, K. Ulbrich. Preparation of DNA complexes with diblock copolymers of poly[N-(2-hydroxypropyl) methacrylamide] and polycations.. Materials Science & Engineering C-Biomimetic and Supramolecular Systems, 1999, 7, 59-65. (Abstract)
  23. V. Toncheva, M. A. Wolfert, P. R. Dash, D. Oupicky, K. Ulbrich, L. W. Seymour, E. H. Schacht. Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers.. Biochimica et Biophysica Acta, 1998, 1380, 354-368. (Abstract)
  24. G. Chen, R. G. Cooks, S. K. Jha, D. Oupicky, M. M. Green. Block microstructural characterization of copolymers formed from fluorinated and non-fluorinated alkyl polyisocyanates using desorption chemical ionization mass spectrometry.. International Journal of Mass Spectrometry and Ion Processes, 1997, 165/166, 391-404. (Abstract)
  25. P. Sysel, D. Oupicky. Polyimide-polysiloxane block copolymers synthesized from 3-amino phenoxy terminated poly[oxy(dimethylsilyl)-2,4-phenylene(dimethylsilylene)]s.. Polymer International, 1996, 40, 275-279 . (Abstract)