2013-present (University of Nebraska Medical Center)

  1. S. Kanvinde, Y. S. Chhonker, R. Ahmad, F. Yu, R. Sleightholm, W. Tang, L. Jaramillo, Y. Chen, Y. Sheinin, J. Li, D. J. Murry, A. B. Singh, D. Oupicky. Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease. Acta Biomaterialia, 2018, in press.
  2. Z. Zhou, C. Li, M. Zhang, Q. Zhang, C. Qian, D. Oupicky, M. Sun. ATP-activated decrosslinking and charge-reversal vectors for siRNA delivery and cancer therapy. Theranostics, 2018, 8, 4604-4619.
  3. Z. Zhou, Q. Zhang, M. Zhang, H. Li, G. Chen, C. Qian, D. Oupicky, M. Sun. Charge and Assembly Reversible Micelles Fueled by Intracellular ATP for Improved siRNA Transfection. ACS Applied Materials & Interfaces, 2018, in press.
  4. P. Wu, X. Luo, H. Wu, F. Yu, K. Wang, M. Sun, D. Oupicky. Cholesterol modification enhances antimetastatic activity and siRNA delivery efficacy of poly(ethylenimine)-based CXCR4 antagonists. Macromolecular Bioscience, 2018, in press.
  5. G. Chen, Y. Wang, P. Wu, Y. Zhou, F. Yu, C. Zhu, Z. Li, Y. Hang, K. Wang, J. Li, M. Sun, D. Oupicky. Reversibly Stabilized Polycation Nanoparticles for Combination Treatment of Early- and Late-Stage Metastatic Breast Cancer. ACS Nano, 2018, 12, 6620-6636.
  6. X. Zhou, M. Zhang, Y. Liu, C. Li, Q. Zhang, D. Oupicky, M. Sun. Reversible Covalent-Crosslinked Polycations with Enhanced Stability and ATP-Responsive Behavior for Improved siRNA Delivery. Biomacromolecules: NBM, 2018, in press.
  7. X. Yang, H. Li, C. Qian, Y. Guo, C. Li, F. Gao, Y. Yang, K. Wang, D. Oupicky, M. Sun. Near-infrared light-activated IR780-loaded liposomes for anti-tumor angiogenesis and photothermal therapy. Nanomedicine: NBM, 2018, in press.
  8. N. K. Routhu, Y. Xie, M. Dunworth, R. A. Casero, D. Oupicky, S. N. Byrareddy. Polymeric Prodrugs Targeting Polyamine Metabolism Inhibit Zika Virus Replication in Epithelial and Glioblastoma Cells. Molecular Pharmaceutics, 2018, in press.
  9. Y. Xie, Y. Wang, J. Li, Y. Hang, L. Jaramillo, C. J. Wehrkamp, M. A. Phillippi, A. M. Mohr, Y. Chen, G. A. Talmon, J. L. Mott, D. Oupicky. Cholangiocarcinoma therapy with nanoparticles that combine downregulation of MicroRNA-210 with inhibition of cancer cell invasiveness. Theranostics, 2018, 8, 4305-4320.
  10. G. Chen, L. Ding, P. Wu, Y. Zhou, M. Sun, K. Wang, D. Oupicky. Polymeric Micelleplexes for Improved Photothermal Endosomal Escape and Delivery of siRNA. Polymers for Advanced Technologies, 2018, in press.
  11. L. Ding, C. Zhu, F. Yu, P. Wu, G. Chen, A. Ullah, K. Wang, M. Sun, J. Li, D. Oupicky. Pulmonary delivery of polyplexes for combined PAI-1 gene silencing and CXCR4 inhibition to treat lung fibrosis. Nanomedicine: NBM, 2018, 14, 1765-1776.
  12. Y. Xie, Y. Wang, J. Li, Y. Hang, D. Oupicky. Promise of Chemokine Network-Targeted Nanoparticles in Combination Nucleic Acid Therapies of Metastatic Cancer. WIREs Nanomedicine and Nanobiotechnology, 2018, e1528.
  13. R. Sleightholm, B. Neilsen, D. Oupicky, M. J. Baine. Prognostic and Predictive Factors for Recurrence in Head and Neck Squamous Cell Carcinoma. In Head and Neck Cancer. 2018, in press.
  14. H. Li, Z. Zhou, F. Zhang, Y. Guo, X. Yang, H. Jiang, F. Tan, D. Oupicky, M. Sun. A networked swellable dextrin nanogels loading Bcl2 siRNA for melanoma tumor therapy. Nano Research, 2018, in press.
  15. H. Li, X. Yang, F. Gao, C. Qian, C. Li, D. Oupicky, M. Sun. Bioreduction-ruptured nanogel for switch on/off release of Bcl2 siRNA in breast tumor therapy. Journal of Controlled Release, 2018, in press.
  16. R. N. Kularatne, K. E. Washington, C. Bulumulla, M. C. Biewer, D. Oupicky, M. C. Stefan. Histone Deacetylase Inhibitor (HDACi) Conjugated Polycaprolactone for Combination Cancer Therapy. Biomacromolecules, 2018, 19, 1082-1089.
  17. Y. Zhou, F. Yu, F. Zhang, G. Chen, K. Wang, M. Sun, J. Li, D. Oupicky. Cyclam-modified PEI for combined VEGF siRNA silencing and CXCR4 inhibition to treat metastatic breast cancer. Biomacromolecules, 2018, 19, 392-402.
  18. Y. Chen, J. Li, D. Oupicky. Conjugate polyplexes with anti-invasive properties and improved siRNA delivery in vivo. Bioconjugate Chemistry, 2018, 29, 296-305.
  19. G. Chen, K. Wang, P. Wu, Y. Wang, Z. Zhou, L. Yin, M. Sun, D. Oupicky. Development of fluorinated polyplex nanoemulsions for improved siRNA delivery and cancer therapy. Nano Research, 2018, in press.
  20. Y. S. Chhonker, R. L. Sleightholm, J. Li, D. Oupicky, D. J. Murry. Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC–ESI–MS/MS: An application for pharmacokinetic studies. Journal of Chromatography B, 2018, 1072, 320-327.
  21. G. Chen, K. Wang, Y. Wang, P. Wu, M. Sun, D. Oupicky. Fluorination enhances serum stability of bioreducible poly(amido amine) polyplexes and enables efficient intravenous siRNA delivery. Advanced Healthcare Materials, 2018, 7, 1701070.
  22. J. Li, C. Zhang, J. Chen, W. He, H. Qiao, K. Wang, D. Oupicky, M. Sun. Coordination-driven assembly of catechol-modified chitosan for kidney-specific delivery of salvianolic acid B to treat renal fibrosis. Biomaterials Science, 2018, 6, 179-188.
  23. M. Sun, K. Wang, D. Oupicky. Advances in stimulus-responsive polymeric materials for systemic delivery of nucleic acids. Advanced Healthcare Materials, 2017, 7, 1701070.
  24. Y. Xie, F. Yu, W. Tang, B. Alade, Z. Peng, Y. Wang, J. Li, D. Oupicky. Chloroquine-containing DMAEMA copolymers as efficient anti-miRNA delivery vectors with improved endosomal escape and anti-migratory activity in cancer cells. Macromolecular Bioscience, 2017, 18, 1700194.
  25. R. L. Sleightholm, B. Yang, F. Yu, Y. Xie, D. Oupicky. Chloroquine-Modified Hydroxyethyl Starch as a Polymeric Drug for Cancer Therapy. Biomacromolecules, 2017, 18, 2247-2257.
  26. H. Li, X. Yang, Z. Zhou, K. Wang, C. Li, H. Qiao, D. Oupicky, M. Sun. Near-infrared light-triggered drug release from a multiple lipid carrier complex using an all-in-one strategy. Journal of Controlled Release, 2017, 261, 126-137.
  27. R. L. Sleightholm, B. K. Neilsen, J. Li, M. M. Steele, R. K. Singh, M. A. Hollingsworth, D. Oupicky. Emerging Roles of the CXCL12/CXCR4 Axis in Pancreatic Cancer Progression and Therapy. Pharmacology & Therapeutics, 2017, 179, 158-170.
  28. F. Zhang, S. Gong, J. Wu, H. Li, D. Oupicky, M. Sun. CXCR4-targeted and redox responsive dextrin nanogel for metastatic breast cancer therapy. Biomacromolecules, 2017, 18, 1793-1802.
  29. A. Wani, G. H. Layan Savithra, A. Abyad, S. Kanvinde, J. Li, S. Brock, D. Oupicky. Surface PEGylation of Mesoporous Silica Nanorods (MSNR): Effect on loading, release, and delivery of mitoxantrone in hypoxic cancer cells. Scientific Reports, 2017, 7, 2274.
  30. Z. Zhou, H. Li, K. Wang, Q. Guo, C. Li, H.L. Jiang, Y. Hu, D. Oupicky, M. Sun. Bioreducible Cross-Linked Hyaluronic Acid/Calcium Phosphate Hybrid Nanoparticles for Specific Delivery of siRNA in Melanoma Tumor Therapy. ACS Applied Materials & Interfaces, 2017, 9, 14576-14589.
  31. T. Murray-Stewart, E. Ferrari, Y. Xie, F. Yu, L. J. Marton, D. Oupicky, R. A. Casero. Biochemical evaluation of the anticancer potential of the polyamine based nanocarrier Nano11047. PLOS One, 2017, 12, e0175917.
  32. K. Wang, G. Chen, Q. Hu, Y. Zhen, H. Li, J. Chen, B. Di, Y. Hu, M. Sun, D. Oupicky. Self-assembled hemoglobin nanoparticles for improved oral photosensitizer delivery and photothermal therapy in vivo. Nanomedicine, 2017, 12, 1043-1055.
  33. S. Senevirathne, K. E. Washington, J. B. Miller, M. C. Biewer, D. Oupicky. D. J. Siegwart, M. C. Stefan. HDAC Inhibitor Conjugated Polymeric Prodrug Micelles for Doxorubicin Delivery. Journal of Materials Chemistry B, 2017, 5, 2106-2114.
  34. M. Sun, J. Li, C. Zhang, Y. Xie, H. Qiao, Z. Su, D. Oupicky, Q. Ping. Arginine-Modified Nanostructured Lipid Carriers with Charge-Reversal and pH-Sensitive Membranolytic Properties for Anticancer Drug Delivery. Advanced Healthcare Materials, 2017, 6, 1600693.
  35. Y. Wang, Y. Xie, J. Li, Z. Peng, Y. Sheinin, J. Zhou, D. Oupicky. Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy. ACS Nano, 2017, 11, 2227-2238.
  36. H. Li, K. Wang, X. Yang, Y. Zhou, Q. Ping, D. Oupicky, M. Sun. Dual-function nanostructured lipid carriers to deliver IR780 for breast cancer treatment: anti-metastatic and photothermal anti-tumor therapy. Acta Biomaterialia, 2017, 53, 399-413.
  37. G. Chen, K. Wang, Q. Hu, L. Ding, F. Yu, Z. Zhou, Y. Zhou, J. Li, M. Sun, D. Oupicky. Combining fluorination and bioreducibility for improved siRNA polyplex delivery. ACS Applied Materials & Interfaces, 2017, 9, 4457-4466.
  38. Z. Peng, Y. Xie, Y. Wang, J. Li, D. Oupicky. Dual-function polymeric HPMA prodrugs for the delivery of miRNA. Molecular Pharmaceutics, 2017, 14, 1395-1404.
  39. Y. Xie, T. Murray-Stewart, Y. Wang, F. Yu, J. Li, L. J. Marton, R. A. Casero, D. Oupicky. Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy. Journal of Controlled Release, 2017, 246, 110-119.
  40. G. Chen, K. Wang, Y. Zhou, L. Ding, A. Ullah, Q. Hu, M. Sun, D. Oupicky. Oral nanostructured lipid carriers loaded with near-infrared dye for image-guided photothermal therapy. ACS Applied Materials & Interfaces, 2016, 8, 25087-25095.
  41. F. Yu, J. Li, R. L. Sleightholm, Y. Xie, D. Oupicky. Polymeric chloroquine as an inhibitor of cancer cell migration and experimental lung metastasis. Journal of Controlled Release, 2016, 244, 347-356.
  42. Y. Wang, S. Kumar, S. Rachagani, B. R. Sajja, Y. Xie, Y. Hang, M. Jain, J. Li, M. D. Boska, S. K. Batra, D. Oupicky. Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis. Biomaterials, 2016, 101, 108-120.
  43. Y. Xie, C. Wehrkamp, J. Li, Y. Wang. Y. Wang, J. Mott, D. Oupicky. Delivery of miR-200c mimic with poly(amido amine) CXCR4 antagonists for combined inhibition of cholangiocarcinoma cell invasiveness. Molecular Pharmaceutics, 2016, 13, 1073-1080
  44. Y. Wang, Y. Xie, D. Oupicky. Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery. Current Pharmacology Reports, 2016, 2(1), 1-10
  45. F. Yu, Y. Xie, Y. Wang, Z. Peng, J. Li, D. Oupicky. Chloroquine-containing HPMA Copolymers as Polymeric Inhibitors of Cancer Cell Migration Mediated by the CXCR4/SDF-1 Chemokine Axis. ACS Macro Letters, 2016, 5, 342-345
  46. M. Saraswathy, D. Oupicky. Endosomal escape into cytosol. in Drug Delivery Across Physiological Barriers, CRC Press, S. Muro, Ed., 2016, pp. 341-360.
  47. J. Li, F. Yu, Y. Chen, D. Oupicky. Polymeric drugs: Advances in the development of pharmacologically active polymers. Journal of Controlled Release, 2015, 219, 369-382.
  48. Y. Wang, J. Li, Y. Chen, D. Oupicky. Balancing polymer hydrophobicity for ligand presentation and siRNA delivery in dual function CXCR4 inhibiting polyplexes. Biomaterials Science, 2015, 3, 1114-1123.
  49. S. Senevirathne, S. Boonsith, D. Oupicky, M. C. Biewer, M. C. Stefan. Synthesis and characterization of valproic acid ester substituted amphiphilic polycaprolactone block copolymers. Polymer Chemistry, 2015, 6(13), 2386-2389.
  50. Y. Wang, S. Hazeldine, J. Li, D. Oupicky. Development of functional poly(amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids. Advanced Healthcare Materials, 2015, 4(5), 729-738.
  51. Y. Zhu, J. Li, S. Kanvinde, Z. Lin, S. Hazeldine, R. K. Singh, D. Oupicky. Self-immolative polycations as gene delivery vectors and prodrugs targeting polyamine metabolism in cancer. Molecular Pharmaceutics, 2015, 12(2), 332-341.
  52. Y. Wang, J. Li, D. Oupicky. Polymeric Plerixafor: Effect of PEGylation on CXCR4 Antagonism, Cancer Cell Invasion, and DNA Transfection. Pharmaceutical Research, 2014, 31(12), 3538-3548.
  53. J. Li, A. M. Lepadatu, Y. Zhu, M. Ciobanu, Y. Wang, S. C. Asaftei, D. Oupicky. Examination of structure-activity relationship of viologen-based dendrimers as CXCR4 antagonists and gene carriers. Bioconjugate Chemistry, 2014, 25(5), 907-917.
  54. J. Li, D. Oupicky. Effect of biodegradability on CXCR4 antagonism, transfection efficacy and antimetastatic activity of polymeric Plerixafor. Biomaterials, 2014, 35(21), 5572-5579.
  55. R. Roggers, S. Kanvinde, S. Boonsith, D. Oupicky. The Practicality of Mesoporous Silica Nanoparticles as Drug Delivery Devices and Progress Toward This Goal. AAPS PharmSciTech, 2014, 15(5), 1163-1171.
  56. D. Oupicky, J. Li. Bioreducible Polycations in Nucleic Acid Delivery: Past, Present, and Future Trends. Macromolecular Bioscience, 2014, 14(7), 908-922.
  57. Y. Zhu, J. Li, Y. Wang, D. S. Manickam, Y. You, D. Oupicky. Redox-responsive polymer-based gene delivery systems. In Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. 4th Edition, Ed. N. S. Templeton, Taylor and Francis/CRC Press, Boca Raton, 2014.
  58. Y. Zou, D. Oupicky, G. Mao. Atomic Force Microscopy Imaging of DNA Delivery Nanosystems. In NanoCellBiology: Multimodal Imaging in Biology and Medicine, B. P. Jena and D. J. Taatjes, Eds., Pan Stanford Publishing, Chapter 11, 2014.
  59. Y. Zhu, S. Hazeldine, J. Li, D. Oupicky. Dendritic Polyglycerol with Secondary Amine Shell as an Efficient Gene Delivery Vector with Reduced Toxicity. Polymers for Advanced Technologies, 2014, 25(9), 940-947.
  60. C. Wu, J. Li, Y. Zhu, J. Chen, D. Oupicky. Opposing Influence of Intracellular and Membrane Thiols on the Toxicity of Reducible Polycations. Biomaterials, 2013, 34(34), 8843-50.
  61. J. Li, Y. Wang, Y. Zhu, D. Oupicky. Recent Advances in Delivery of Drug-Nucleic Acid Combinations for Cancer Treatment. Journal of Controlled Release, 2013, 172(2), 589-600.
  62. J. Yuan, H. Zhang, H. Kaur, D. Oupicky, F. Peng. Synthesis and Characterization of Theranostic Poly(HPMA)-c(RGDyK)-DOTA-64Cu Copolymer Targeting Tumor Angiogenesis: Tumor Localization Visualized by Positron Emission Tomography. Molecular Imaging, 2013, 12(3), 203-12.
  63. M. F. Ebbesen, D. Schaffert, M. L. Crowley, D. Oupicky, K. A. Howard. Synthesis of click-reactive HPMA copolymers using RAFT polymerization for drug delivery applications. Journal of Polymer Science Part A: Polymer Chemistry, 2013, 51(23), 5091-9.

2003-2013 (Wayne State University)

  1. J. Li, Y. Zhu, S. Hazeldine, C. Li, D. Oupicky. “Dual-function CXCR4 Antagonist Polyplexes to Deliver Gene Therapy and Inhibit Cancer Cell Invasion.” Angewandte Chemie, International Edition, 2012, 51(35), 8740-3. (Abstract)
  2. J. Li, Y. Zhu, S. T. Hazeldine, S. M. Firestine, D. Oupicky. “Cyclam-based Polymeric Copper Chelators for Gene Delivery and Potential PET Imaging.” Biomacromolecules, 2012, 13, 3220-7. (Abstract)
  3. A. Wani, E. Muthuswamy, G. H. L. Savithra, G. Mao, S. Brock, D. Oupicky. “Surface Functionalization of Mesoporous Silica Nanoparticles Controls Loading and Release Behavior of Mitoxantrone.” Pharmaceutical Research, 2012, 29(9), 2407-2418. (Abstract)
  4. Y. Dong, Y. Zhu, J. Li, Q. Zhou, C. Wu, D. Oupicky. “Synthesis of bisethylnorspermine lipid prodrug as gene delivery vector targeting polyamine metabolism in breast cancer.” Molecular Pharmaceutics, 2012, 9(6), 1654-64. (Abstract)
  5. J. Li, D. S. Manickam, J. Chen, D. Oupicky. “Effect of cell membrane thiols and reduction-triggered disassembly on transfection activity of bioreducible polyplexes.” European Journal of Pharmaceutical Sciences, 2012, 46(3), 173-80. (Abstract)
  6. M. B. Dewal, A. S. Wani, C. Vidaillac, D. Oupicky, M. J. Rybak, S. M. Firestine. “Thieno[2,3-d]pyrimidinedione derivatives as antibacterial agents.” European Journal of Medicinal Chemistry, 2012, 51, 145-153. (Abstract)
  7. Y. Zou, J. Blacklock, D. Oupicky, G. Mao. “In Situ Analysis Investigating Disassembly of DNA Nanoparticles and Nano-Films.” In Nanotechnology for Nucleic Acid Delivery: Methods and Protocols (Methods in Molecular Biology series), M. Ogris and D. Oupicky, Eds., Humana Press, Vol. 948, 2013, 183-193
  8. Y. Z. Yu, J. J. Yan, Z. Q. Yu, D. Oupicky. “Synthesis of Bioreducible Polycations with Controlled Topologies.” In Nanotechnology for Nucleic Acid Delivery: Methods and Protocols (Methods in Molecular Biology series), M. Ogris and D. Oupicky, Eds., Humana Press, Vol. 948, 2013, 121-32
  9. Y. Zhu, J. Li, D. Oupický. “Intracellular Delivery Considerations for RNAi Therapeutics.” In RNA Interference from Biology to Therapeutics, K. A. Howard, Ed., Springer, New York, 2012.
  10. Y. Wu, S. Wang, S. M. Farooq, M. P. Castelvetere, Y. Hou, J. Gao, J. V. Navarro, D. Oupicky, F. Sun, C. Li. “A chemokine receptor CXCR2 macromolecular complex regulates neutrophil functions in inflammatory diseases.” Journal of Biological Chemistry, 2012, 278(8), 5744-55. (Abstract)
  11. U. L. Rahbek, A. F. Nielsen, M. Dong, Y. You, A. Chauchereau, D. Oupicky. F. Besenbacher, J. Kjems, K. A. Howard. “Bioresponsive hyperbranched polymers for siRNA and miRNA delivery.” Journal of Drug Targeting, 2010, 18(10), 812-20. (Abstract)
  12. D. Oupicky. “Polymeric Biomaterials for Gene and Drug Delivery.” Pharmaceutical Research, 2010, 27(12), 2517-19. (Abstract)
  13. S. R. Bhattarai, E. Muthuswamy, A. Wani, M. Brichacek, A. L. Castaneda, S. Brock, D. Oupicky. “Enhanced gene and siRNA delivery by polycation-modified mesoporous silica nanoparticles loaded with chloroquine.” Pharmaceutical Research, 2010, 27(12), 2556-68. (Abstract)
  14. Y. Dong, J. Li, C. Wu, D. Oupicky. “Bisethylnorspermine lipopolyamine as potential delivery vector for combination drug/gene anticancer therapies.” Pharmaceutical Research, 2010, 27(9), 1927-38. (Abstract)
  15. J. Blacklock, A. Vetter, A. Lankenau, D. Oupicky, H. Möhwald. “Turning the mechanical properties of bioreducible multilayer films for improved cell adhesion and transfection activity.” Biomaterials, 2010, 31, 7167-74. (Abstract)
  16. R. Regmi, S. R. Bhattarai, C. Sudakar, A. S. Wani, R. Cunningham, P. P. Washnava, R. Naik, D. Oupicky, G. Lawes. “Hyperthermia Controlled Rapid Drug Release from Thermosensitive Magnetic Microgels.” Journal of Materials Chemistry, 2010, 20, 6158-63. (Abstract)
  17. M. O. Andersen, A. Lichawska, A. Arpanaei, S. M. Rask Jensen, H. Kaur, D. Oupicky, F. Besenbacher, P. Kingshott, J. Kjems, K. A. Howard. “Surface Functionalisation of PLGA Nanoparticles for Gene Silencing.” Biomaterials, 2010, 31(21), 5671-77. (Abstract)
  18. J. Blacklock, T. K. Sievers, H. Handa, Y. Z. You, D. Oupicky, G. Mao, H. Möhwald. “Cross-Linked Bioreducible Layer-by-Layer Films for Increased Cell Adhesion and Transgene Expression.” Journal of Physical Chemistry B, 2009, 114(16), 5283-91. (Abstract)
  19. J. Blacklock, G. Mao, D. Oupicky, H. Möhwald. “DNA release dynamics from bioreducible layer-by-layer films.” Langmuir, 2010, 26(11), 8597-8605. (Abstract)
  20. D. S. Manickam, J. Li, D. A. Putt, Q. H. Zhou, C. Wu, L. H. Lash, D. Oupicky. “Effect of innate glutathione levels on activity of redox-responsive gene delivery vectors.” Journal of Controlled Release, 2010, 141(1), 77-84. (Abstract)
  21. J. Chen, C. Wu, D. Oupicky. “Bioreducible Hyperbranched Poly(amido amine)s for Gene Delivery.” Biomacromolecules, 2009, 10(10), 2921-27. (Abstract)
  22. L. Shin, N. Basi, J. S. Lee, W. J. Cho, Z. Chen, R. Abu-Hamdah, D. Oupicky, B. P. Jena. “Involvement of vH+-ATPase in synaptic vesicle swelling.” Journal of Neuroscience Research, 2010, 88(1), 95-101. (Abstract)
  23. L. Wan, Y. Z. You, Y. Zou, D. Oupicky, G. Mao. “DNA release dynamics from bioreducible poly(amido amine) polyplexes.” Journal of Physical Chemistry B, 2009, 113(42), 13735-41. (Abstract)
  24. Q. Zhou, C. Wu, D. S. Manickam, D. Oupicky. “Evaluation of pharmacokinetics of bioreducible gene delivery vectors by real-time PCR.” Pharmaceutical Research, 2009, 26(7), 1581-1589. (Abstract)
  25. Q. H. Zhou, Y. Z. You, C. Wu, Y. Huang, D. Oupicky. “Cyclic RGD-targeted reversibly-stabilized nanoparticles enhance cell uptake and transfection in vitro.” Journal of Drug Targeting, 2009, 17(5), 364-373. (Abstract)
  26. J. Blacklock, Y. Z. You, Q. H. Zhou, G. Mao, D. Oupicky. “Gene delivery in vitro and in vivo from bioreducible multilayered polyelectrolyte films of plasmid DNA.” Biomaterials, 2009, 30, 939-950. (Abstract)
  27. S. Kakade, D. S. Manickam, H. Handa, G. Mao, D. Oupicky. “Transfection activity of layer-by-layer plasmid DNA/poly(ethylenimine) films deposited on PLGA microparticles.” International Journal of Pharmaceutics, 2009, 365, 44-52. (Abstract)
  28. D. Oupicky. “Design and development strategies of polymer materials for drug and gene delivery applications (Preface)” Advanced Drug Delivery Reviews, 2008, 60, 957. (Issue)
  29. L. Wan, D. S. Manickam, D. Oupicky, G. Mao. “DNA Release Dynamics from Reducible Polyplexes by Atomic Force Microscopy.” Langmuir, 2008, 24, 12474-12482. (Abstract)
  30. Oupicky, Y. You, D. Soundara Manickam. “Redox-responsive polymer-based gene delivery systems.” In Gene and Cell Therapy: Therapeutic Mechanisms and Strategies (3rd edition), N. Smyth Templeton, Ed., Taylor&Francis, 2008.
  31. D. S. Manickam, A. Hirata, D. A. Putt, L. H. Lash, F. Hirata, D. Oupicky. “Overexpression of Bcl-2 as a proxy redox stimulus to enhance activity of non-viral redox-responsive delivery vectors.” Biomaterials, 2008, 29, 2680-2688. (Abstract)
  32. Y. You, K. Kalebaila, S. L. Brock, D. Oupicky. “Temperature-Controlled Uptake and Release in PNIPAM-modified Porous Silica Nanoparticles.” Chemistry of Materials, 2008, 20, 3354-3359. (Abstract)
  33. U. L. Rahbek, K. A. Howard, D. Oupicky, D. S. Manickam, M. Dong, A. F. Nielsen, F. Besenbacher, J. Kjems. “Intracellular siRNA and Precursor miRNA Trafficking Using Bioresponsive Copolypeptides.” Journal of Gene Medicine, 2008, 10, 81-93. (Abstract)
  34. H. Zhang, R. Thomas, D. Oupicky, F. Peng. “Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells.” Journal of Biological Inorganic Chemistry, 2008, 13, 47-55. (Abstract)
  35. Y. Z. You, Q. H. Zhou, D. S. Manickam, L Wan, G. Mao, D. Oupicky. “Dually Responsive Multiblock Copolymers via Reversible Addition-Fragmentation Chain Transfer Polymerization: Synthesis of Temperature- and Redox-Responsive Copolymers of Poly(N-isopropylacrylamide) and Poly(2-(dimethylamino)ethyl methacrylate).” Macromolecules, 2007, 40(24), 8617-8624. (Abstract)
  36. L. Wan, H. S. Bisht, Y. You, D. Oupicky, G. Mao. “Temperature-Reversible Ultrathin Films of N-Isopropylacrylamide Terpolymer Adsorbed at the Solid-Liquid Interface.” Langmuir, 2007, 23, 12159-12166. (Abstract)
  37. Y. You, D. Soundara Manickam, Q. Zhou, D. Oupický. “Reducible poly(2-dimethyl aminoethyl methacrylate): Synthesis, cytotoxicity, and gene delivery activity.” Journal of Controlled Release, 2007, 122, 217-225. (Abstract)
  38. Y. You, D. Soundara Manickam, Q. Zhou, D. Oupicky. “A versatile approach to reducible vinyl polymers via oxidation of telechelic oligomers prepared by RAFT polymerization.” Biomacromolecules, 2007, 8, 2038-2044. (Abstract)
  39. M. Dong, K. A. Howard, D. Oupicky, H. Bisht, J. Kjems, F. Besenbacher. “Visualisation of thermal activated nanocarriers using in situ atomic force microscopy.” Nanotechnology, 2007, 18(18), 185501 5(pp). (Abstract)
  40. Y. You, D. Oupicky. “Synthesis of temperature-responsive heterobifunctional block copolymers of PEG and PNIPAM.” Biomacromolecules, 2007, 8, 98-105. (Abstract)
  41. J. Blacklock, H. Handa, D. Soundara Manickam, G. Mao, A. Mukhopadhy, D. Oupicky. “Disassembly of Layer-by-Layer Films of Plasmid DNA and Reducible TAT Polypeptide.” Biomaterials, 2007, 28, 117-124. (Abstract)
  42. K. A. Howard, M. Dong, D. Oupicky, H. S. Bisht, C. Buss, F. Besenbacher, J. Kjems. “Nanocarrier Stimuli-Activated Drug Delivery.” Small, 2007, 3, 54-57. (Abstract)
  43. J. Yuan, Y. You, X. Lu, O. Muzik, D. Oupicky, F. Peng. “Synthesis of Poly(APMA)-DOTA-64Cu conjugates for interventional radionuclide therapy of prostate cancer: Assessment of intra-tumoral retention by microPET imaging.” Molecular Imaging, 2007, 6, 10-17. (Abstract)
  44. D. Soundara Manickam, D. Oupicky. “Multiblock reducible copolypeptides containing histidine-rich and nuclear localization sequences for gene delivery.” Bioconjugate Chemistry, 2006, 17, 1395-1403. (Abstract)
  45. D. Soundara Manickam, D. Oupicky. “Polyplex gene delivery modulated by redox potential gradients.” Journal of Drug Targeting, 2006, 14, 519-526. (Abstract)
  46. H. S. Bisht, D. Soundara Manickam, Y. You, D. Oupicky. “Temperature-Controlled Properties of DNA Complexes with Poly(ethylenimine)-graft-poly(N-isopropylacrylamide).” Biomacromolecules, 2006, 7, 1169-1178. (Abstract)
  47. Q. Zhou, D. L. Miller, R. C. Carlisle, L. W. Seymour, D. Oupicky. “Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation.” Journal of Controlled Release, 2005, 106, 416-427. (Abstract)
  48. H. S. Bisht, L. Wan, G. Mao, D. Oupicky. “pH-Controlled association of PEG-containing terpolymers of N-isopropylacrylamide and 1-vinylimidazole.” Polymer, 2005, 46, 7945-7952. (Abstract)
  49. D. Oupicky, H. S. Bisht, D. Soundara Manickam, Q. Zhou. “Stimulus-controlled delivery of drugs and genes.” Expert Opinion on Drug Delivery, 2005, 2, 653-665. (Abstract)
  50. M. L. Read, S. Singh, Z. Ahmed, M. Stevenson, S. Briggs, D. Oupicky, L. Barrett, U. Tirlapur, M. Berry, J. Preece, A. Logan, L. W. Seymour. “A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids.” Nucleic Acids Research, 2005, 33(9), e86. (Full text)
  51. A. L. Parker, K.D. Fisher, D. Oupicky, M. L. Read, S. A. Nicklin, A. H. Baker, L. W. Seymour. “Enhanced gene transfer activity of peptide-targeted gene-delivery vectors.” Journal of Drug Targeting, 2005, 13, 39-51. (Abstract)
  52. D. Soundara Manickam, H. S. Bisht, L. Wan, G. Mao, D. Oupicky. “Influence of TAT-peptide polymerization on properties and transfection activity of TAT/DNA polyplexes.” Journal of Controlled Release, 2005,102, 293-306. (Abstract)
  53. D. Oupicky. “Subcellular Fate of Proteins and Nucleic Acids.” In Biomaterials-based Delivery and Biocompatibility of Proteins and Nucleic Acids, R. I. Mahato, Ed., CRC Press, 2005.
  54. D. Oupicky. “Use of HPMA Copolymers in Gene Delivery.” In Polymeric Gene Delivery: Principles and Applications, M. M. Amiji, Ed., CRC Press, 2004.
  55. D. Oupicky, T. Reschel, C. Konak, L. Oupicka. “Temperature controlled behavior of self-assembly gene delivery vectors based on complexes of DNA with poly(L-lysine)-graft-poly(N-isopropylacryl amide).” Macromolecules, 2003, 36, 6863-6872. (Abstract)
  56. L. W. Seymour, K. D. Fisher, N. K. Green, S. J. Hale, M. Lyons, V. Mautner, S. Nicum, D. Onion, D. Oupicky, M. Stevenson, K. Ulbrich “Adenovirus Retargeting and Systemic Delivery” In Human Gene Therapy: Present opportunities and future trends, G. M. Rubanyi and S. Yla-Herttuala, Eds., Ernst Schering Research Foundation Workshop Series, Volume 43, Springer Verlag, Heidelberg, 2003. (Abstract)
  57. D. Oupicky, V. Diwadkar. “Stimuli-responsive gene delivery vectors.” Current Opinion in Molecular Therapeutics, 2003, 5, 345-350. (Abstract)
  58. M. L. Read, K. H. Bremner, D. Oupicky, N. K. Green, P. F. Searle, L. W. Seymour. “Vectors based on reducible polycations facilitate intracellular release of nucleic acids.” Journal of Gene Medicine, 2003, 5, 232-245. (Abstract)

1996-2002 (Institute of Macromolecular Chemistry (Prague) and University of Birmingham)

  1. D. Oupicky, A. L. Parker, L. W. Seymour. “Laterally stabilized complexes of DNA with linear reducible polycations: Strategy for triggered intracellular activation of DNA delivery vectors.” Journal of the American Chemical Society, 2002, 124, 8-9. (Abstract)
  2. D. Oupicky, M. Ogris, K. A. Howard, P. R. Dash, K. Ulbrich, and L. W. Seymour. “Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation.” Molecular Therapy, 2002, 5, 463-472. (Abstract)
  3. C. Konak, T. Reschel, D. Oupicky, K. Ulbrich. “Thermally controlled association in aqueous solutions of poly(L-lysine) grafted with poly(N-isopropylacrylamide).” Langmuir, 2002, 18, 8217-8222. (Abstract)
  4. C. M. Ward, M. Pechar, D. Oupicky, K. Ulbrich and L. W. Seymour. “Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo.” Journal of Gene Medicine, 2002, 4, 536–547. (Abstract)
  5. T. Reschel, C. Konak, D. Oupicky, L.W. Seymour , K. Ulbrich. “Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations.” Journal of Controlled Release, 2002, 81 201-217. (Abstract)
  6. A. L. Parker, D. Oupicky, P. R. Dash, L. W. Seymour. “Methodologies for monitoring particle formation by self-assembly of DNA with poly(L-lysine).” Analytical Biochemistry, 2002, 302, 75-80. (Abstract)
  7. D. Oupicky, M. Ogris, L. W. Seymour. “Development of long-circulating polyelectrolyte complexes for systemic delivery of genes.” Journal of Drug Targeting, 2002, 10, 93-98. (Abstract)
  8. M. L. Read, T. Bettinger, D. Oupicky. “Methods for studying the formation and stability of polycation-DNA complexes.” In Nonviral Vectors for Gene Therapy (Methods in Molecular Medicine series), M. A. Findeis, Ed., Humana Press, Totowa, Vol. 65, 131-148, 2001.
  9. D. Oupicky, M. L. Read, T. Bettinger. “Stabilization of polycation/DNA complexes by surface modification with hydrophilic polymers.” In Nonviral Vectors for Gene Therapy (Methods in Molecular Medicine series), M. A Findeis, Ed., Humana Press, Totowa, Vol. 65, 61-78, 2001.
  10. D. Oupicky, R. C. Carlisle, L.W. Seymour. “Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo.” Gene Therapy, 2001, 8(9), 713-724. (Abstract)
  11. J. Kriz, D. Kurková, J. Dybal, D. Oupicky. “Cooperative interactions of unlike macromolecules: NMR study of ionic coupling of poly[2-(trimethylammonio)ethyl methacrylate chloride]-block-poly(N-(2-hydroxypropyl) methacrylamide) polycation with oligophosphates in D2O.” Journal of Physical Chemistry A, 2000, 104, 10972-10985. (Abstract)
  12. C. Konak, D. Oupicky, V. Chytry, K. Ulbrich, M. Helmstedt. “Thermally controlled association in aqueous solutions of diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropylacryl-amide).” Macromolecules, 2000, 33, 5318-5320. (Abstract)
  13. D. Oupicky, K. A. Howard, C. Konak, P. R. Dash, K. Ulbrich, L.W. Seymour. “Steric stabilization of poly-L-lysine/DNA complexes by covalent attachment of semitelechelic poly[N-(2-hydroxypropyl)methacryl-amide].” Bioconjugate Chemistry, 2000, 11, 492-501. (Abstract)
  14. P. R. Dash, M. Read, K. Fisher, K. Howard, M. Wolfert, D. Oupicky, M. Šubr, J. Strohalm, K. Ulbrich and L. W. Seymour. “Decreased binding to proteins and cells of polymeric gene delivery vectors surface-modified with a multivalent hydrophilic polymer.” Journal of Biological Chemistry, 2000, 275, 3793-3802. (Full text)
  15. D. Oupicky, C. Konak, K. Ulbrich, M. A. Wolfert, L. W. Seymour. “DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers.” Journal of Controlled Release, 2000, 65, 149-171. (Abstract)
  16. M. L. Read, P. Dash, A. Clark, K. Howard, D. Oupicky, V. Toncheva, O. Alpar, E. H. Schacht, K. Ulbrich and L. W. Seymour. “Physicochemical and biological characterisation of an antisense oligonucleotide targeted against the bcl-2 mRNA complexed with cationic-hydrophilic copolymers.” European Journal of Pharmaceutical Sciences, 2000, 10, 169-177. (Abstract)
  17. K. Ulbrich, J. Strohalm, D. Plocová, D. Oupicky, V. Šubr, J. Soucek, P. Poucková, J. Matoušek. “Poly[N-(2-hydroxypropyl)methacrylamide] conjugates of bovine seminal ribonuclease. Synthesis, physicochemical, and preliminary biological evaluation.” Journal of Bioactive and Compatible Polymers, 2000, 15, 4-26. (Abstract)
  18. D. Oupicky, C. Konak, P. R. Dash, L. W. Seymour, K. Ulbrich. “Effect of albumin and polyanions on the structure of DNA complexes with polycation containing hydrophilic nonionic blocks.” Bioconjugate Chemistry, 1999, 10(5), 764-772. (Abstract)
  19. M. A. Wolfert, P. R. Dash, O. Nazarova, D. Oupicky, L. W. Seymour, S. Smart, J. Strohalm, K. Ulbrich. “Polyelectrolyte vectors for gene delivery: Influence of cationic polymer on biophysical properties of complexes formed with DNA.” Bioconjugate Chemistry, 1999, 10, 993-1004. (Abstract)
  20. D. Oupicky, C. Konak, K. Ulbrich. “DNA complexes with block and graft copolymers of N-(2-hydroxypropyl)methacrylamide and 2-(trimethylammonio)ethyl methacrylate.” Journal of Biomaterials Science: Polymer Edition, 1999, 10, 573-590. (Abstract)
  21. D. Oupicky, C. Konak, K. Ulbrich. “Preparation of DNA complexes with diblock copolymers of poly[N-(2-hydroxypropyl) methacrylamide] and polycations.” Materials Science & Engineering C-Biomimetic and Supramolecular Systems, 1999, 7, 59-65. (Abstract)
  22. D. Oupicky, K. Ulbrich, B. Rihova. “Conjugates of semitelechelic poly[N-(2-hydroxypropyl) methacrylamide] with enzymes for protein delivery.” Journal of Bioactive and Compatible Polymers, 1999, 14, 213-231. (Abstract)
  23. V. Toncheva, M. A. Wolfert, P. R. Dash, D. Oupicky, K. Ulbrich, L. W. Seymour, E. H. Schacht. “Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers.” Biochimica et Biophysica Acta, 1998, 1380, 354-368. (Abstract)
  24. G. Chen, R. G. Cooks, S. K. Jha, D. Oupicky, M. M. Green. “Block microstructural characterization of copolymers formed from fluorinated and non-fluorinated alkyl polyisocyanates using desorption chemical ionization mass spectrometry.” International Journal of Mass Spectrometry and Ion Processes, 1997, 165/166, 391-404. (Abstract)
  25. P. Sysel, D. Oupicky. “Polyimide-polysiloxane block copolymers synthesized from 3-amino phenoxy terminated poly[oxy(dimethylsilyl)-2,4-phenylene(dimethylsilylene)]s.” Polymer International, 1996, 40, 275-279 . (Abstract)